Berberine is an alkaloid found in several plants (Berberis, goldenseal, Oregon grape). It activates AMPK — the cellular energy sensor and metabolic master switch — producing effects similar to metformin on blood glucose, lipids, and mitochondrial function. Multiple RCTs compare it favourably to metformin for type 2 diabetes management, with additional benefits for lipid profiles and gut microbiome.

Key Benefits

Blood glucose control
Cholesterol & triglyceride reduction
Weight management
PCOS management
Gut microbiome modulation
Antimicrobial activity

Best Form

Berberine HCl; berberine phytosome (Berbevis) for improved absorption

Dosage

500 mg 2–3× daily with meals (total 1,000–1,500 mg/day)

⚠ Safety Notes

GI side effects (nausea, constipation, diarrhoea) are common — start low. Not safe in pregnancy. Significant drug interactions (see interactions). Cycle use (8 weeks on, 4 weeks off) often recommended.

This page is for educational purposes only. Consult a healthcare professional before starting any supplement.