L-Glutamine is the most abundant amino acid in the bloodstream and a critical fuel source for rapidly dividing cells — particularly intestinal epithelial cells, immune cells, and kidney tubule cells. During illness, trauma, or intense exercise, glutamine becomes conditionally essential as demand exceeds supply. Its primary supplemental use is supporting gut barrier integrity (preventing and healing leaky gut) and supporting immune function during physiological stress.

Key Benefits

Intestinal barrier integrity ('leaky gut')
Post-exercise immune suppression prevention
Muscle recovery (reduced catabolism)
IBS and IBD symptom relief
Wound healing
Alcohol withdrawal support (preliminary)

Best Form

L-Glutamine powder (most economical); fermented L-glutamine for purity

Dosage

5–20 g/day (gut healing); 2–5 g post-exercise

⚠ Safety Notes

Generally safe. May exacerbate mania in bipolar disorder. People with liver disease or epilepsy should use caution (glutamine is a precursor to excitatory glutamate and inhibitory GABA). Not for use in glutamine-responsive tumours without oncologist approval.

This page is for educational purposes only. Consult a healthcare professional before starting any supplement.