5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and the immediate precursor to serotonin (5-HT). Derived from the seeds of Griffonia simplicifolia, it crosses the blood-brain barrier and raises serotonin levels more directly than L-tryptophan. Because serotonin cannot cross the blood-brain barrier, 5-HTP (which can) is the preferred supplemental route to raising brain serotonin.

Key Benefits

Depression support
Sleep onset (via serotonin → melatonin conversion)
Appetite control and weight management
Anxiety reduction
Fibromyalgia pain
Migraine prevention

Best Form

Standard 5-HTP; sustained-release formulas for mood stability

Dosage

50–300 mg/day (start at 50 mg to assess tolerance)

⚠ Safety Notes

Do NOT combine with SSRIs, MAOIs, tramadol, triptans, or St John's Wort — risk of serotonin syndrome (potentially life-threatening). Always inform your doctor. Never exceed 400 mg/day. May cause GI nausea — take with food.

This page is for educational purposes only. Consult a healthcare professional before starting any supplement.