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Magnesium L-Threonate

The only magnesium form clinically shown to raise brain magnesium levels

Evidence Grade: B — Good clinical evidence Nootropics
B
Evidence Grade B: Good clinical evidence Based on the volume and quality of published human clinical trials.

Magnesium L-threonate (MgT) is a synthetic form of magnesium specifically developed by MIT researchers to cross the blood-brain barrier efficiently. All other magnesium forms raise peripheral blood and tissue magnesium; MgT uniquely raises brain magnesium concentrations. Animal studies show it reverses synaptic density decline, enhances long-term potentiation (memory formation), and reduces neuroinflammation. Human trials (Magtein brand) are promising but still limited.

Key Benefits

  • Brain magnesium elevation
  • Memory and learning
  • Cognitive ageing prevention
  • Anxiety (brain-targeted)
  • Sleep quality with cognitive benefits

Best Form

Magtein (patented MgT) — no generic equivalent has the same human evidence

Dosage

1,500–2,000 mg/day (providing ~144 mg elemental magnesium)

⚠ Safety Notes

Safe; same profile as general magnesium. GI side effects at high doses. More expensive than other magnesium forms. Combine with regular magnesium glycinate for full-body + brain coverage.

This page is for educational purposes only. Consult a healthcare professional before starting any supplement.