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Hormones

DHEA

The adrenal hormone that declines sharply with age

Evidence Grade: C — Preliminary evidence Hormones
C
Evidence Grade C: Preliminary evidence Based on the volume and quality of published human clinical trials.

Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal cortex, gonads, and brain. It is the most abundant circulating steroid hormone in the body and a precursor to both testosterone and oestrogen. DHEA levels peak at age 25 and decline 80–90% by age 70. Interest centres on replacing this decline to support energy, libido, cognitive function, and body composition. Evidence is mixed — most benefits seen in people with low DHEA-S levels.

Key Benefits

  • Age-related decline compensation
  • Libido and sexual function
  • Bone density in postmenopausal women
  • Mood and depression
  • Muscle mass and energy (in deficiency)

Best Form

Micronised DHEA (better absorption); 7-keto DHEA (non-androgenic; does not convert to sex hormones)

Dosage

25–50 mg/day (always under medical guidance)

⚠ Safety Notes

Do NOT take without a DHEA-S blood test and medical supervision. DHEA is a hormone and can cause androgenic side effects (acne, facial hair in women, hair loss) and may worsen hormone-sensitive cancers. Not appropriate for anyone under 40.

This page is for educational purposes only. Consult a healthcare professional before starting any supplement.